TY - GEN AU - Barrios-Gonzalez, J. AU - Fernandez, F. J. AU - Tomasini, A. TI - Microbial secondary metabolites production and strain improvement KW - secondary metabolites, new activities, classical and molecular genetic improvement N2 - Microbial secondary metabolites are compounds produced mainly by actinomycetes and fungi, usually late in the growth cycle (idiophase). Although antibiotics are the best known secondary metabolites (SM), there are others with an enormous range of other biological activities mainly in fields like: pharmaceutical and cosmetics, food, agriculture an farming ER -