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2-Am,4,6-DNT causes genotoxicity of P53 gene in NG108 neuroblastoma cell lines
By: Banerjee, H. N.
Contributor(s): Verma, M | Dutta, S. K.
Subject(s): 2 AM-DNT, p53 | gene | Ng 108 cells In: International Journal of Human Genetics 4(4)Summary: The 2-Amino, 4,6-dinitrotoluene)2Am-DNT) is a non-enzymatic chemical metabolite of TNT (trintro toluene) which is an important hazardous environmental pollutant. Genomic DNA was isolated from the NG108 cells treated with 2 Am-DNT for seven hours and also frokm untreated cells. DNA spanning p53 tumor suppressor gene exons 6-9 and parts of exon 5 and 10 was PCR amplified from both the control and treated genomic DNA's.| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| Journal | Indira Gandhi Rashtriya Manav Sangrahalaya | Available |
The 2-Amino, 4,6-dinitrotoluene)2Am-DNT) is a non-enzymatic chemical metabolite of TNT (trintro toluene) which is an important hazardous environmental pollutant. Genomic DNA was isolated from the NG108 cells treated with 2 Am-DNT for seven hours and also frokm untreated cells. DNA spanning p53 tumor suppressor gene exons 6-9 and parts of exon 5 and 10 was PCR amplified from both the control and treated genomic DNA's.