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Mapping of human hexokinase 1 gene to 10q11-qter

By: Daniele, Aurora.
Contributor(s): Altruda, Fiorella | Ferrone, Marina.
Subject(s): Hexokinase type 1. Human gene mapping. Chromosome 10 In: Human Heredity 42(2)Summary: Two partial-length cDNAs encoding the type 1 human hexokinase (ATP: D-hexose 6-phosphotransferase) were isolated from a placenta cDNA library using a 50-bp oligonucleotide synthesized according to the known sequence of human HK1. Using the larger (1.8 kb) cDNA insert as a probe and a panel of human-hamster somatic cell hybrids, we were able to assing the HK1 gene to the long arm of chromosome 10.
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Journal Indira Gandhi Rashtriya Manav Sangrahalaya
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Two partial-length cDNAs encoding the type 1 human hexokinase (ATP: D-hexose 6-phosphotransferase) were isolated from a placenta cDNA library using a 50-bp oligonucleotide synthesized according to the known sequence of human HK1. Using the larger (1.8 kb) cDNA insert as a probe and a panel of human-hamster somatic cell hybrids, we were able to assing the HK1 gene to the long arm of chromosome 10.